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© The Author(s) (202. Published by Oxford University Press on the part of the Guarantors of mind. All rights reserved. For permissions, please email journals.permissions@oup.com.Direct-acting antivirals (DAA) targeting hepatitis C virus (HCV) have transformed outcomes in HIV co-infection. We examined early events in liver and plasma through A5335S, a substudy of trial A5329 (paritaprevir/ritonavir, ombitasvir, dasabuvir, with ribavirin) that enrolled persistent genotype