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Notably, the killing capacity of CD4+ Vγ9Vδ2 T cells correlates with co-expression of CD56. In patients with muscle-invasive urothelial bladder cancer (MIBC), molecular alterations in immunotherapy-resistant tumors found at radical cystectomy (RC) remain largely unstudied. To investigate the biology of pembrolizumab-resistant tumors in comparison to an RC cohort treated without any systemic therapy and a cohort of neoadjuvant chemotherapy (NAC)-treated tumors. Transcriptome-wide expression profiling was performed on 26 RC samples from pat