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BACKGROUND Intracytoplasmic lumina (ICL) are observed in several cancers, including urothelial carcinoma (UC). We have reported that ICL in urine cytology (cICL) is more frequent in high-grade UCs than in low-grade UCs; however, the correlation between the presence of ICL and prognosis is unclear. OBJECTIVES The aim of this work was to determine the association between cICL and prognosis in bladder cancer. METHOD We retrospectively investigated 87 patients with bladder cancer who received a histological diagnosis within 3 months of urine