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To discover most appropriate guide region to cut back the variance in the Aβ CL unit between 18F-florbetaben (FB and 18F-flutemetamol (FMM), we conducted head-to-head comparisons from 56 participants making use of the direct comparison of FBB-FMM CL (dcCL) technique with four reference areas cerebellar gray (CG), entire cerebellum (WC), WC with brainstem (WC + , and pons. The FBB and FMM dcCL products were very correlated in four reference regions WC (R2 = 0.97