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Conclusion Oxidative stress preconditioning can enhance the anti-oxidative stress ability of BMSCs and promote its survival under oxidative stress.Objective To study the effects of microRNA-139 (miR-139) regulating Notch signaling pathway on bone mesenchymal stem cells (BMSCs) homing and asthma airway inflammation. Methods Twenty-four SD rats were randomly divided into normal control group, model control group and BMSCs group. The rats were challenged with ovalbumin and then BMSCs were transplanted into the rats. Pathological changes in