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The cellular response consisted of an acute neutrophil influx followed by different monocyte subsets and dendritic cells. Intradermal LPS administration in humans causes an acute, localized and transient inflammatory reaction that is well-tolerated by healthy volunteers. This may be a valuable inflammation model for evaluating the pharmacological activity of anti-inflammatory investigational compounds in proof of pharmacology studies. Intradermal LPS administration in humans causes an acute, localized and transient inflammatory reaction