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https://www.selleckchem.com/pr....oducts/Abitrexate.ht
Atypical hemolytic uremic syndrome (aHUS) is a rare, progressive, life-threating disease that frequently has a genetic component; it is usually caused by familial, sporadic or idiopathic reasons. We report a case of aHUS in a 21-month-old girl with coexisting of methylenetetrahydrofolate reductase mutations, homocysteinemia and thalassemia minor complicated by peripheral gangrene as extrarenal manifestation. several genetic disorders are known to be associated with congenital insensitivity to pain (CIP), a term often used to describe