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In inclusion, aided by the stimulation of NETs, the expression of vascular endothelial development factor A (VEGF-A) and hypoxia-inducible factor-1α (HIF-1α) were increased, that have been related to the pathological apparatus of KD. At last, we examined the activation of phosphoinositide 3 kinase (PI3K)/Akt signaling, and we found NETs treatment obviously enhanced the activation of PI3K and Akt. In summary, these findings proposed that the forming of NETs may affect the bio