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We will herein talk about the offered data into the epigenetic variations leading to disease discordance in MZ twins for systemic lupus erythematosus, rheumatoid arthritis symptoms, and systemic sclerosis.The research of epigenetics has its roots into the study of organism change-over some time response to ecological change, although over the past several years the definition was formalized to incorporate heritable alterations in gene appearance that aren't due to changes in underlying DNA sequence. I