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Vaso-occlusive crisis is the most common clinical feature requiring opioid analgesics in patients with sickle cell disease. We conducted a network meta-analysis to compare the drugs that can be used as add-on with opioids for vaso-occlusive crisis. Network meta-analysis of randomized clinical trials. Sickle cell disease patients with vaso-occlusive crisis receiving adjuvants to opioids for pain management. A number of patients with complete pain relief and pain scores assessed either by visual ana-log or by a numerical rating scale were