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Despite much improvement in the treatment for acute lymphoblastic leukemia (ALL), childhood ALLs with -rearrangement ( -r) still have inferior dismal prognosis. Thus, defining mechanisms underlying -r ALL maintenance is critical for developing effective therapy. GSE13159 and GSE28497 were selected the Oncomine website. Differentially expressed genes (DEGs) between -r ALLs and normal samples were identified by R software. Next, functional enrichment analysis of these DEGs were carried out by Gene Ontology (GO), Kyoto Encyclopedia of Genes