https://www.selleckchem.com/pr....oducts/ndi-091143.ht
This study aimed to evaluate the impact of ketorolac on the pharmacokinetics of 5-FU and its effect on the efficacy of 5-fluorouracil (5-FU) on the HT-29 cell line. Cell culture the HT-29 cell line was treated with different concentrations of 5-FU, ketorolac, and combination of 5-FU and ketorolac for 24 and 48 hours. The cell viability (%) was calculated by the MTT assay. Animal study rats were randomly divided into control and pretreatment groups. The control group received physiological saline, whereas the pretreatment group receiv