https://www.selleckchem.com/pr....oducts/17-AAG(Geldan
Metabolic reprogramming is a hallmark of malignancy. Testes-specific protease 50 (TSP5, a newly identified oncogene, has been shown to play an important role in tumorigenesis. However, its role in tumor cell metabolism remains unclear. To investigate this issue, LC-MS/MS was employed to identify TSP50-binding proteins and pyruvate kinase M2 isoform (PKM2), a known key enzyme of aerobic glycolysis, was identified as a novel binding partner of TSP50. Further studies suggested that TSP50 promoted aerobic glycolysis in HCC ce
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