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Biomarker studies are needed to test the hypothesis that resilience of the elderly during a pandemic can be improved by countering chronic inflammation and/or removing senescent cells. Our review suggests that more samples should be taken and saved systematically, following minimum standards, and data be made available, to maximize healthspan minimize frailty, leading to savings in health care, gains in quality of life, and preparing us better for the next pandemic, all at the same time.Background While endoscopy is recommended at