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The work in this paper is of great significance for the generation of miniaturized multi-channel VBs and for broadening the applications of metasurfaces.Single-molecule force spectroscopy has opened a new field of research in molecular biophysics and biochemistry. Pulling experiments on individual proteins permit us to monitor conformational transitions with high temporal resolution and measure their free energy landscape. The force-extension curves of single proteins often present large hysteresis, with unfolding forces that are higher
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