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The present study suggested that Z. tenuior extract, as a traditional treatment can be able to moderate CPF toxicity via significant effect on inflammatory and apoptotic cell death signaling pathway. Also, based on our preliminary data, it is suggested that Z. tenuior extract can prevent the adverse effects of CPF in liver and lung tissues. The present study suggested that Z. tenuior extract, as a traditional treatment can be able to moderate CPF toxicity via significant effect on inflammatory and apoptotic cell death signaling pathway.