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The Driver-Pressure-State-Impact-Response (DPSIR) framework is applied for assessing the pressures and impacts on groundwater bodies of two Mediterranean sites (Megara and Oropos-Kalamos basins). The study areas present joint driving forces (drivers) and pressures. The main driving forces in the areas studied mainly include geology, agricultural activities, and urban development, while the main pressures mainly include the weathering of ultramafic rock masses, application of agrochemicals, and groundwater abstractions for irrigation and d