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95, 95% confidence interval [CI] 1.13-3.34, P=0.0154), as well as the log-transformed CACS (adjusted HR 1.24, 95% CI 1.11-1.39, P=0.0002) and the presence of obstructive stenosis (adjusted HR 5.63, 95% CI 3.22-10.12, P 0.0001). In subgroup analyses, high-risk plaques were independently predictive only in the low CACS class (10. This study shows that assessment of adverse features by coronary plaque imaging independently predicts coronary events in patients with suspected CAD and a low CACS. Our findings suggest that the clinical va