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To investigate the effects of red blood cell (RBC) transfusion on sublingual microcirculation in critically ill patients. Systematic strategy was conducted to search studies that measured sublingual microcirculation before and after transfusion in critically ill patients. This review was reported according to the Preferred Reporting Items for Systematic Review and Meta-Analyses Scoping Review Extension. The literature search yielded 114 articles. A total of 11 studies met the inclusion criteria. Observational evidence showed diffusive