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Previous studies have shown that PLD1 promotes cellular expansion and prevents apoptosis, suggesting that PLD1 might be implicated in the pathogenesis of renal injury caused by Cd. Researches in vivo plus in vitro all illustrate that the mRNA and protein degrees of PLD1 reduce significantly in both renal muscle plus in proximal tubular cell outlines exposed to Cd. Overexpression of PLD1 and its own downstream product PA could ameliorate Cd-induced apoptosis. Moreover, we