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However, RP modulated the toxicogenic effects of antineoplastic tested both in the CBMN test (P less then 0.05), at the concentrations of 1, 10 and 100 IU/mL; as in the comet assay (P less then 0.001) at the concentration of 100 IU/kg for the index and frequency of genotoxic damage. The accumulated results suggest that RP reduced the action of antineoplastics in non-tumor cells as well as the cytotoxic, mutagenic, and cell death in neoplastic cells.It is becoming clearer how neurobiological mechanisms generate 'liking' and 'wanting' com