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4 vs. 58.9±22.1 µmol*h/L); they also showed a better glycemic response and more reduction of blood pressure following ingestion of a NO3-rich meal. T2DM may be associated with a different pattern of NOx pharmacokinetics (especially salivary NOx metabolism). Salivary NR activity may have a critical role in postprandial metabolism of NO3, and diabetic patients with higher NR activity may take more advantages from NO3 supplementation. T2DM may be associated with a different pattern of NOx pharmacokinetics (especially salivary NOx metabolis