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Potential applications of high-sensitive NGS in oncology along with comparison with non-NGS orthogonal technologies of similar capabilities are also summarized.This review tackles the concept of the evolutionary mismatch, in relation with the reduction of the prevalence of the so-called "dirty old friends". These formed the variegated community of parasites and microorganisms, either prokaryotic or eukaryotic, that, over long evolutionary times, co-evolved with humans and their ancestors, inhabiting their digestive tracts, and other body districts. This com
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