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uster had lower CRP levels. Specific adversities and adversity combinations are important for differences in childhood inflammation. Some associations were only observed for girls or boys. Specific adversities and adversity combinations are important for differences in childhood inflammation. Some associations were only observed for girls or boys. Data regarding real-world impact on cancer clinical research during COVID-19 are scarce. We analysed the impact of the COVID-19 pandemic on the conduct of paediatric cancer phase I-II trials