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© The Author(s) 2020. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.Single-cell transcriptomics offers unprecedented possibilities to infer the ligand-receptor (LR) interactions fundamental mobile sites. We introduce a fresh, curated LR database and a novel regularized score to perform such inferences. The very first time, we you will need to gauge the confidence in predicted LR interactions and show that our regularized rating outperf