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Hypoxia induced by flooding or submergence is a serious abiotic stress affecting crop productivity worldwide. During evolution, plants have developed different metabolism mechanisms to cope with the energy crisis caused by hypoxia stress. Among those, the metabolism of γ-aminobutyric acid (GABA), a non-protein amino acid, is recognized as a crucial component for low-oxygen stress responses because of its link both in carbon and nitrogen metabolism. However, it is largely unknown how to control GABA homeostasis. In this study, we identif