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In this industry, monoclonal antibodies against epidermal growth element receptor (anti-EGFR) added to a chemotherapy doublet have demonstrated enhanced total success for these patients. Nonetheless, mutations in oncogenes NRAS/KRAS tend to be predictive of absence of reaction to these treatments. Therefore, genotyping in mCRC is essential to personalized treatment. It really is understood that tumoral heterogeneity and discerning pression by targeted treatments can lead to changes in RAS mutati
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