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Exposure to adverse environmental conditions such as toxic chemicals, viral infections, and even stress during pregnancy or early life may disrupt the development of normal brain and its functioning leading to incidence of neurodevelopmental disorders at later stages of life. Recently, we reported that poly (IC) exposure altered synaptic plasticity protein level and impaired memory through activation of microglia cells. As epigenetic modifications are involved in memory formation, we have studied methylation of DNA and acetylation of hi