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73; 95% confidence interval (CI) 1.10-2.71; P=0.018). The risk of local recurrence was not significantly increased at 5 years (pOR 1.00; 95% CI 0.49-2.04; P=0.995) and 10 years (pOR 1.52; 95% CI 0.72-3.23; P=0.275). Individuals with LCIS in association with invasive breast cancer have an increased risk of local recurrence following breast conservation therapy. This supports consideration of increased medical surveillance and exploration of further risk reduction strategies for such patients. Individuals with LCIS in association with invasive breast cancer h
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