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Preoperative differential diagnosis from retroperitoneal liposarcoma are challenging. A 66-year-old female patient ended up being accepted due to a sizable cyst during the right retroperitoneal space, incidentally found during stomach ultrasonography for screening function. Preoperative imaging studies were indicative for the diagnosis of a huge adrenal myelolipoma (11.7 × 12.9 cm in proportions); nonetheless, a retroperitoneal liposarcoma could not be excluded. We chose to co