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This short article is a component of a Special concern entitled The MLL family of proteins in normal development and disease edited by Thomas A Milne. Glioblastoma multiforme (GBM) is the most aggressive (which grade IV) as a type of diffuse glioma endowed with tremendous invasive capacity. The option of slim therapeutic options for GBM administration adds to the irony, even the post-treatment median success time is roughly around 14-16 months. Gene mutations seem to be cardinal to GBM development, owing to involv