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The COST1 protein negatively regulates autophagy by direct communication with the crucial autophagy adaptor ATG8E, hence directly linking autophagy and drought tolerance. More over, plant development and development in a cost1 mutant is significantly retarded, suggesting that COST1 controls the tradeoff between growth and anxiety threshold.BACKGROUND Left ventricular worldwide longitudinal stress (GLS) is involving long-lasting outcomes of custome