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To compare COVID-19 related knowledge, perceptions, and preferred information sources between healthcare workers and non-healthcare workers. Cross-sectional survey. Web-based. Convenience sample of Pennsylvanian adults. Primary outcomes were binary responses to 15 COVID-19 knowledge questions weighted by a Likert scale assessing response confidence. Generalized linear mixed-effects models to assess comparisons between clinical decision makers (CDM), non-clinical decision makers working in healthcare (non-CDM) and non-healthcare workers (non-HCW). CDMs (n =