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7 months (range 8.8-10.5 months), and in Vp4 PVTT, the TTP was 4.2 months (range 2.8-5.6 months). The median OS was 10.0 months (range 7.0-13.1 months). In Vp3 PVTT, OS was 11.9 months (range 9.2-14.5 months), and in Vp4 PVTT, OS was 7.2 months (range 3.8-10.7 months). Conclusions PVS-125I-TACE-S is safe for patients with HCC with PVTT and may extend the TTP and survival of patients with Vp4 PVTT. Advances in knowledge PVS implantation promptly restored flow in the obstructed portal vein, which can reduce the risk of hepatic failure a