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Here we report that the increased appearance of lymphoid enhancer binding factor 1 (Lef1) is linked to the TNM (tumor- node-metastasis) stage of gastric disease. Subsequently, 2,4-diamino-quinazoline (2,4-DAQ), a selective inhibitor of Lef1, had been identified to control the phrase of Wnt/β-catenin target genes such as for instance AXIN2, MYC and LGR5 and result in the suppression of gastric disease mobile growth through the apoptotic path. The 2,4-DAQ also exhi