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Current literature revealed significantly difference between 2 techniques and suggested that RA might be beneficial for patients than freehand method. Numerous studies have investigated the associations between Vitamin D receptor (VDR) gene polymorphisms and risk of intervertebral disc degeneration but the results remain controversial. This study aimed to drive a more precise estimation of association between VDR gene polymorphisms and risk of intervertebral disc degeneration. PubMed, EMBASE, Cochrane library, Web of Science and China