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The enhanced olfactory light bulb blood flow peaked at 30 ± 7% using stimulation parameters of 300 μA and 20 Hz. Nerve stimulation would not change frontal cortical circulation or mean arterial pressure. The intravenous injection of smoking (30 μg/kg) augmented the olfactory light bulb blood circulation response to nerve stimulation (20 Hz, 300 μA) by approximately 1.5-fold (60-s location following the stimulation). These results suggest that olfactory nerve stimulatio