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02 vs GDM) and the increased miR-518d expression (P=0.009 vs GDM). Increased proinflammatory markers (interleukin-1β, tumor necrosis factor-α and nitric oxide overproduction) in GDM placentas were prevented by the EVOO-enriched diet (respectively P=0.001, P=0.001 and P=0.01 vs GDM). MMPs overactivity was prevented in placenta and umbilical cord blood in the EVOO-enriched GDM group (MMP-9 respectively P=0.01 and P=0.001 vs GDM). Conclusions A diet enriched in EVOO in GDM patients reduced maternal triglyceridemia and weight gain and has