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iagnosis thanks to these studies. Since only likely pathogenic and pathogenic variants are clinically actionable, this work shows the importance of functional studies for variant classification.We analyzed spatial and temporal variations in total mercury concentration (THg) in Mytilus californianus from the west coast of Baja California, México, and assessed the potential risk for human health. The sites from the northern zone showed the highest levels of THg over the entire three years of study, however, no significant differences among