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To determine the preponderance and the distribution of pathological lesions in oral and maxillofacial region reported in and around the Madurai city. Retrospective study on the oral and maxillofacial biopsies taken during 11 years period from 2007 to 2018 in a CSI Dental College, Madurai, Tamilnadu. A total of 1000 cases were analyzed and 904 were selected. The parameters recorded were age, sex, area, and the histopathological report obtained. Descriptive statistics was used for analysis. The most common soft tissue lesion was t