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All of the new substances were examined with regards to their anti inflammatory activities by inhibiting the lipopolysaccharide (LPS)-induced nitric oxide (NO) launch in RAW264.7 cells, 2 with an IC50 price of 3.46 μM. Pyridazinone analogues have now been known to be potential applicants for anticonvulsant representatives. We have identified several pyridazinone-based anticonvulsant representatives. As a continuation to our past study, a number of hybrid pyridazinone-thiazole co