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Intraoperative parathyroid hormones (IOPTH) determination is dependent on the short half-life of parathyroid hormone (PTH) and also the rapid analytical technology. The IOPTH provides useful details about modification of this overproductive state in hyperparathyroidism (HPT) and is better than macroscopic assessment for the parathyroid gland (PG) along with any (intraoperative frozen part) kind of histology (alleged biochemical frozen section). In this article the relevance and evaluation