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87, 95% CI 0.77, 0.98) were associated with adherence to MAT. Self-efficacy was directly associated with adherence to MAT (β = 0.347, P less then 0.05). Perceive benefits (β = 0.276, P less then 0.01) and perceived barriers (β = -0.241, P less then 0.05) were directly associated with self-efficacy. However, perceived benefits (β = 0.096, P less then 0.01) and perceived barriers (β = -0.084, P less then 0.01) were only indirectly associated with adherence to MAT. CONCLUSION The adherence of heroin-dependent patients to MAT can be expla