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Moreover, the termination of the primary drying out phase was predicted using both doubt evaluation and a comparative force measurement method. Both the forecast of T i and end of primary drying were in agreement using the experimental information. Hence, it had been confirmed that the proposed real-time control method can perform mitigating the effect of modest disruptions during batch freeze-drying.In this study, the physicochemical and surface properties of the GO-Ag composite promote a synergistic antibacter