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Moreover, VASP was implicated in the insulin- and HG-dependent dynamic remodeling of the actin cytoskeleton and, consequently, increased podocyte permeability to albumin under hyperinsulinemic and hyperglycemic conditions. These results indicate that insulin- and HG-dependent regulation of albumin permeability is mediated by the PKGIα/VASP pathway in cultured rat podocytes. This molecular mechanism may explain podocytopathy and albuminuria in diabetes.Introduction The British Columbia Ministry of Health launched a Smoking Cessation Program on September 30th