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depending on the substance, the EEG emergence patterns showed significant differences that led to a substance-specific early activation of higher frequencies as indicated by the "wake" CSI values that occurred minutes before ROR in the inhalational anesthetic groups. our results highlight substance-specific differences in the emergence from anesthesia that can influence the EEG-based monitoring that probably have to be considered in order to improve neuromonitoring during general anesthesia. our results highlight substance-specific dif