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Synaesthetes did not differ in grapheme or colour thresholds relative to non-synaesthete controls. These results are consistent with the proposal of differential neural mechanisms underlying photism perception in subtypes of grapheme-colour synaesthesia and warrant renewed attention to heterogeneity in the mechanisms and phenomenology of this condition.Curcumin is a bioactive natural compound with a wide range of pharmacological properties, including antitumor activity; however, its clinical application has been limited because of its l