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In the case of the nonenveloped polyomavirus SV40, penetration of the ER membrane to reach the cytosol is a decisive virus infection step. In this study, we found a new host factor called Ubqln4 that facilitates escape of SV40 from the ER into the cytosol, thereby providing a path for the virus to enter the nucleus to cause infection. Copyright © 2020 American Society for Microbiology.In the 21st century, the emergence of H7N9 and H1N1/2009 influenza viruses originating from animals and causing severe human infections has prompted invest
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