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This research aimed to measure the bone depth and thickness of different insertion paths for safe placement of infrazygomatic crest miniscrews between the first (U6) and second maxillary molars (U7) by 3-dimensional (3D) reconstruction and to explore their clinical significance. Cone-beam computed tomography data from 36 adult orthodontic patients were obtained to generate 3D models (n=72) of the infrazygomatic crest region. For each model, the bone depth and thickness of 27 different insertion paths were measured in the region between