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908; sensitivity 96.3%, specificity 78.9%) and MSA (AUC 0.974; sensitivity 100%, specificity 94.7%) and good accuracy for AP-Tau (AUC 0.718; sensitivity 77.8%, specificity 89.5%). A diagnostic model based on EV marker expression correctly classified 88.9% of patients with reliable diagnostic performance after internal and external validations. Immune profiling of plasmatic EVs represents a crucial step toward the identification of biomarkers of disease for PD and AP. Immune profiling of plasmatic EVs represents a crucial step toward th